The “porous bone” disease, Osteoporosis, happens when the body loses bone, creates too little bone, or both. Osteoporotic bones lose density and carry abnormal tissue structure. The bones become less dense, weaken, and have a greater probability to break. Though different types of medications are available to treat osteoporosis, CBD has emerged as a safe and effective alternative for this condition due to its bone healing properties and furthering the endocannabinoid system health within bones.
Osteoporosis – What It Is?
Osteoporosis, which implies “porous bones”, comprises a condition that leads to gradual thinning and weakening of bones, rendering them susceptible to fractures. Osteoporosis is responsible for nearly two million fractures every year.
Though the disease can affect all bones, the bones of the hip, spine, and wrist are most prone to breaking once effected. Hip fractures may be especially dangerous among elderly people, as the protracted immobility needed for healing can cause blood clots or pneumonia, both of which can prove fatal.
Of the predicted 8.9 million Americans suffering from osteoporosis, nearly 80% comprise women. Experts hold women are more prone as their bones are lighter and less dense and due to hormonal changes following menopause in women’s bodies that speeds up the loss of bone mass.
Causes Of Osteoporosis
The primary cause of osteoporosis is age. During your life, your body replaces and strengthens old bones with fresh calcium. However, when you reach your 30s, the break down of bone by your body is faster than its ability to replace it. This results in less compact and more fragile bones, increasing the likelihood of breakage.
Another main cause of osteoporosis is menopause, which happens in women near the ages of 45 to 55 years. Menopause can lead to quicker bone loss in a woman’s body due to changes in hormone levels.
Men keep on losing bone in this age, but more slowly than women. However, between the ages of 65 to 70, men and women are generally losing bone at a similar rate.
Specific medical conditions like hyperthyroidism can also cause osteoporosis. Use of different medications is also included such as long-term oral or injected corticosteroids like cortisone or prednisone. Vitamin D also plays a role in bone health.
Symptoms Of Osteoporosis
The initial stages of osteoporosis don’t have any visible symptoms or warning signals. In the majority of cases, people with osteoporosis are not aware of the condition until they incur a fracture.
The early symptoms, if present, may comprise:
- Receding Gums
- Brittle and weak nails
- Feeble grip strength
Osteoporosis may worsen without proper treatment. As bones become weaker and thinner, the risk of fracture rises.
Severe osteoporosis symptoms may include a fracture due to a fall or even by a powerful sneeze or cough. They may also have back or neck pain or reduction of height. The latter two symptoms can arise from a compression fracture. This includes a break in a vertebra of your neck or back, which becomes so feeble so as to break under normal spine pressure.
How CBD Helps With Osteoporosis
Scientific research has discovered that Cannabidiol or CBD products may be a nice alternative therapy for osteoporosis. CBD acts on the natural endocannabinoid system of the body, which has been found in studies to be engaged in the regulation of bone density.
Acts On Endocannabinoid Receptors
Recent research has shown CB2 receptors to be present within bone tissue, mainly in the cells that form bone or osteoblasts, besides the cells that reabsorb bone or osteoclasts. These receptors perform a part in the regulation of bone metabolism, aiding to retain the balance between osteoclasts and osteoblasts that support optimal bone wellness. Osteoporosis causes impairment of this balance leading to bone density loss.
CBD acts on the CB2 receptors, raising the osteoblast number and activity, while also restricting osteoclasts. This activates the bone creation and stops bone loss, aiding the body to keep the normal mass of bone. Thereby CBD serves to function as an effective therapy for osteoporosis. CBD also stimulated activity that led to the production of increased levels of lysyl hydroxylase which is an enzyme that plays a major role in osteoblast cells.
Cannabinoid receptors are available within the bone cells. These include CB1, CB2, and orphan receptor GPR55. Researchers curbed the resorption of bones by obstructing these receptors in adult mice. The impact was elevated bone mass and protection of the mice from further loss of bone. Accordingly, they recommend the application of inverse agonists of receptors such as CBD to fight osteoporosis.
In another research, obstructing GPR55 effect caused a rise in trabecular or spongy bone and cortical or outer surface. The mice whose GPR55 receptors were knocked out got fatter and possessed improved protection against age-related bone loss. This led scientists to conclude that administering CBD can be beneficial for osteoporosis patients.
CBD can aid increase formation of bone, lower bone loss and assist the body to maintain normal bone mass.
Promotes Bone Health
The latest study revealed that bones possess greater levels of ligands and endocannabinoids compared to brain cells. Anandamide, which is a naturally generated cannabinoid in the body, has an impact on the bone tissue since it attaches to CB2 receptors. CBD mimics anandamide. These findings made researches to conclude that CBD displays potential health advantages for osteoporosis and health of bone.
Another study concluded that CBD has the capacity to impact ligands and bone metabolism. Thereby, CBD reveals potential health advantages for osteoporosis and bone health as it can be utilized to exploit cannabinoid receptors as the destination for anti-resorptive and anabolic therapy.
A published study in 2015 has discovered that when mice were administered CBD oil, the maximal loads upon their bones increased significantly. It was found that CBD accelerates the process of fracture healing and excels in healing broken bones. In the research, the rodents experienced quicker healing of their femoral bone in 8 weeks.
Moreover, CBD can inhibit different enzymes like FAAH and raise the effects cast by them on the endocannabinoid receptors. These effects made researchers suggest that CBD is effective and useful in reducing the risks of osteoporosis and advancing the health of your endocannabinoid system in the bones.
Conclusion On CBD For Osteoporosis
Presently, the recommended medications to treat and prevent osteoporosis are bisphosphonates. Nevertheless, these drugs exert serious or mild side effects on the patients. The side effects of bisphosphonates comprise unusual heart rate, esophageal inflammation, nausea, and damage to the jaw bone. Though some patients bear the side effects of these drugs, they don’t get to enjoy the therapeutic aid advantages at the end. That’s on account of the patients being prone to develop brittle bones or fractures after 5 or more years even after availing effective therapeutic aid.
In the wake of these serious, unwanted side effects coupled with the inefficacy of the available therapeutic aids, CBD is viewed as a safer and effective alternative and is being recommended by medical researchers for osteoporosis.